10% jakisoni wa Enrofloxacin
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Kanema
Pharmacological Action
Enrofloxacin ndi yotakata sipekitiramu bactericidal wothandizila fluoroquinolone nyama.Kwa Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Porter's sepsis Bacteria, Staphylococcus aureus, Mycoplasmas, Chlamydia, etc. ndi Streptococcus, ndi zotsatira zofooka pa mabakiteriya anaerobic.Iwo ali zoonekeratu antibacterial mphamvu pa tcheru mabakiteriya.Dongosolo la antibacterial la mankhwalawa ndikuletsa bakiteriya DNA gyrase ndikusokoneza kubwerezabwereza kwa bakiteriya kwa DNA, kusindikiza ndi kukonza ndikuphatikizanso.Mabakiteriya sangakule ndi kuberekana bwinobwino n’kufa.
Pharmacokinetics
10% jakisoni wa Enrofloxacinimatengedwa mwachangu komanso kwathunthu ndi jakisoni wa mu mnofu.Bioavailability ya mankhwalawa ndi 91.9% ya nkhumba ndi 82% ya ng'ombe za mkaka.Amagawidwa kwambiri mu nyama ndipo amatha kulowa bwino mu minofu.Kupatula cerebrospinal fluid, ndende ya mankhwalawa pafupifupi pafupifupi minofu yonse ndi yayikulu kuposa ya plasma.Kagayidwe ka chiwindi makamaka kuchotsa ethyl gulu la 7-piperazine mphete kupanga ciprofloxacin, kenako makutidwe ndi okosijeni ndi glucuronic acid kumanga.Imatulutsidwa makamaka kudzera mu impso (kudzera mu katulutsidwe ka aimpso ndi kusefera kwa glomerular), ndipo 15% ~ 50% imatulutsidwa mumkodzo mwanjira yake yoyambirira.Kuchotsa theka la moyo kumasiyana kwambiri pakati pa mitundu yosiyanasiyana ya nyama ndi njira zosiyanasiyana zoyendetsera.Theka la moyo pambuyo jekeseni mu mnofu 5.9 maola ng'ombe, 9.9 maola akavalo, 1.5 kwa 4.5 maola nkhosa, ndi 4.6 maola nkhumba.
Kuyanjana
(1)10% jakisoni wa Enrofloxacinamagwiritsidwa ntchito limodzi ndi aminoglycosides kapena yotakata sipekitiramu penicillin, amene ali synergistic kwenikweni.
(2) Heavy metal ions monga Ca2+, Mg2+, Fe3+ ndi Al3+ amatha chelate ndi mankhwalawa ndikukhudza kuyamwa.
(3) Pophatikizana ndi theophylline ndi caffeine, imatha kuchepetsa kuchuluka kwa mapuloteni a plasma, kuonjezera kuchuluka kwa theophylline ndi caffeine m'magazi, komanso kuyambitsa zizindikiro za poizoni wa theophylline.
(4) mankhwalawa ali ndi zotsatira za inhibiting chiwindi michere mankhwala, amene angathe kuchepetsa chilolezo mlingo wa mankhwala zimapukusidwa mu chiwindi ndi kuonjezera magazi mankhwala ndende.
Ntchito ndi Kugwiritsa Ntchito
Fluoroquinolone antibacterial mankhwala.Amagwiritsidwa ntchito pa matenda a bakiteriya ndi matenda a mycoplasma mu ziweto ndi nkhuku
Mlingo ndi makonzedwe
Mu mnofu jekeseni: mlingo umodzi, pa 1kg thupi, 0.025ml ng'ombe, nkhosa, ndi nkhumba;0.025 ~ 0.05ml ya agalu, amphaka, ndi akalulu.Gwiritsani ntchito 1 mpaka 2 pa tsiku kwa masiku 2 mpaka 3.
Zoyipa
(1) Kuwonongeka kwa cartilage mu nyama zazing'ono, zomwe zimakhudza kukula kwa mafupa ndi kuchititsa claudication ndi ululu.
(2) Zomwe zimachitika m'matumbo am'mimba zimaphatikizapo kusanza, kusowa chidwi, komanso kutsekula m'mimba.
(3) Zomwe zimachitika pakhungu zimaphatikizapo erythema, kuyabwa, urticaria ndi photosensitivity.
(4) Zotsatira zoyipa, ataxia, ndi khunyu nthawi zina zimawonedwa mwa agalu ndi amphaka.
Hebei Veyong pharmaceutical Co., Ltd, unakhazikitsidwa mu 2002, ili mu Shijiazhuang City, Hebei Province, China, pafupi ndi Capital Beijing.Ndi kampani yayikulu yovomerezeka ya GMP yotsimikizira za Chowona Zanyama, yokhala ndi R&D, kupanga ndi kugulitsa ma API a Chowona Zanyama, kukonzekera, zakudya zosakaniza ndi zowonjezera zowonjezera.Monga Provincial Technical Center, Veyong yakhazikitsa njira yatsopano ya R&D yamankhwala atsopano azowona zanyama, ndipo ndi kampani yodziwika bwino yaukadaulo yozikidwa pazanyama, pali akatswiri 65 aukadaulo.Veyong ili ndi zoyambira ziwiri zopangira: Shijiazhuang ndi Ordos, pomwe maziko a Shijiazhuang amatenga malo a 78,706 m2, okhala ndi zinthu 13 za API kuphatikiza Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, ndi 11, mizere yopangira jekeseni, njira yopangira jekeseni. , premix, bolus, mankhwala ndi mankhwala ophera tizilombo, ects.Veyong imapereka ma API, zokonzekera zolembera zopitilira 100, ndi ntchito za OEM & ODM.
Veyong amawona kufunikira kwakukulu ku kasamalidwe ka EHS(Environment, Health & Safety) system, ndipo adalandira ziphaso za ISO14001 ndi OHSAS18001.Veyong adalembedwa m'mabizinesi omwe akutuluka m'chigawo cha Hebei ndipo amatha kuonetsetsa kuti zinthu zikuyenda bwino.
Veyong adakhazikitsa dongosolo lathunthu la kasamalidwe kaubwino, adapeza satifiketi ya ISO9001, satifiketi ya China GMP, satifiketi ya APVMA GMP ya Australia, satifiketi ya GMP ya Ethiopia, satifiketi ya Ivermectin CEP, ndipo idapita ku US FDA.Veyong ali ndi gulu la akatswiri olembetsa, malonda ndi ntchito zaukadaulo, kampani yathu idadalitsidwa ndi chithandizo kuchokera kwamakasitomala ambiri ndi mtundu wabwino kwambiri wazinthu, zogulitsa zapamwamba kwambiri komanso ntchito zotsatsa pambuyo pa malonda, kasamalidwe kakulu ndi sayansi.Veyong wapanga mgwirizano wautali ndi mabizinesi ambiri odziwika padziko lonse lapansi ogulitsa nyama ndi zinthu zomwe zimatumizidwa ku Europe, South America, Middle East, Africa, Asia, etc. mayiko ndi zigawo zopitilira 60.
