Tildipirosin
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Tildipirosin
Tildipirosin ndi mtundu watsopano wa semi-synthetic 16-membered ring macrolide antibiotic kwa nyama, yomwe imachokera ku tylosin.
Pharmacological kanthu
Mphamvu ya antibacterial ya Tildidirosin ndi yofanana ndi ya tylosin, ndipo imakhala ndi mphamvu yoletsa mabakiteriya a Gram-positive ndi mabakiteriya ena a Gram-negative.Njira ya antibacterial ya Tildidirosin ndi yofanana ndi ya macrolides.Ikhoza kuphatikiza ndi 50S subunit ya ribosome ya tcheru mabakiteriya kuti ziletsa synthesis wa riboprotein peptide unyolo, potero zimakhudza synthesis wa mapuloteni bakiteriya.Kuyanjana kwa zigawo ziwiri za piperidine zapadera kwa Tildidirosin kumasiyanitsa njira ya mankhwala awa kuchokera ku tylosin ndi tilmicosin, kumene 20-piperidine imayendetsedwa mu lumen kuti isokoneze kukula kwa ma peptides omwe amatuluka.
Chifukwa tediroxine ili ndi magulu atatu amino amino, imatha kupanga mitundu yosiyanasiyana yolipitsidwa pansi pa pH yosiyana.Kuchuluka kwa ndalama ndi chinthu chofunikira kwambiri chowononga kusungunuka kwa lipids ya bakiteriya ndikulowa mu membrane yakunja ya mabakiteriya a Gram-negative, kotero kuti ntchito ya bacteriostatic ya Tildidirosin in vitro imakhudzidwa kwambiri ndi pH.Pansi acidic mikhalidwe, amino gulu ndi protonated, chifukwa mu kuchepa kwa antibacterial ntchito ya tediroxine, pamene pansi zinthu zamchere, ali wamphamvu antibacterial ntchito.
Macrolides amalepheretsa katulutsidwe ka proinflammatory cytokines, phospholipase ntchito, ndi kutulutsidwa kwa leukotriene, ndipo amakhala ndi anti-yotupa mu macrophages ndi neutrophils.Tediroxine imachepetsa oyimira pakati otupa omwe amapangidwa panthawi yoyankhira kapena kupsinjika.
Antibacterial sipekitiramu
Tildipirosin amagwira ntchito motsutsana ndi mabakiteriya oyambitsa matenda omwe amayambitsa matenda opuma mu nkhumba ndi ng'ombe (monga Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. etc.) antibacterial ntchito ya tilmicosin inali nthawi 2-32 kuposa tilmicosin ya tilmicosin kuposa ya tilmicosin. , ndi antibacterial zochita motsutsana matumbo Escherichia coli anali bwino kuposa tylosin ndi tilmicosin.Imakhudzidwanso ndi mitundu ina ya mycoplasma, spirochetes, brucella, ndi zina zambiri. Kafukufuku wasonyeza kuti tediroxine ili ndi mphamvu ya bacteriostatic pa Haemophilus parasuis ndi Bordetella bronchiseptica kuposa florfenicol, koma mphamvu yofooka ya bacteriostatic pa Actinobacillus pleuropneumoniae ndi Pasteurella multocida.Tildipirosin ndi bactericidal ku mabakiteriya ena (monga Haemophilus parasuis ndi Actinobacillus pleuropneumoniae), pamene makamaka bacteriostatic kwa mabakiteriya ena (monga Pasteurella multocida).Kwa mabakiteriya a m'mimba, ndi kuchepa kwa pH mtengo (kuchokera ku 7.3 mpaka 6.7), MIC ya Tildidirosin inawonjezeka, mwachitsanzo, MIC ya Tildipirosin motsutsana ndi Salmonella Enteritidis ndi Escherichia coli ikhoza kuwonjezeka kuchokera ku 2 ~ 8ug / m mpaka 64 ~ 256ug / mL. .Chifukwa chake, zotsatira za kusintha kwa pH mu vivo ziyenera kuganiziridwa poyesa mu vivo antibacterial test ya Tildidirosin.Kuonjezera apo, MIC ya Tildidirosin motsutsana ndi zovuta za Pasteurella multocida inali 0.5ug / mL mu seramu, yomwe inali nthawi ya 0.25 yotsika kuposa in vitro, yomwe ingakhale yokhudzana ndi zotsatira za seramu.
Enterococcus-Streptococcus mu ng'ombe za mkaka imagonjetsedwa kwambiri ndi tediroxine.Tildipirosin sagwirizana ndi Pasteurella multocida ndi Mannheimia haemolyticus yonyamula majini osinthika.Momwemonso, mitundu yosinthidwa chibadwa ya M. bovis imagonjetsedwa ndi ma macrolide antibiotics kuphatikizapo Tildidirosin.Mitundu ina ya Haemophilus parasuis yapezekanso kukhala yosamva tediroxine.Mycoplasma bovis imatha kukana Tildidirosin mwachangu, koma chifukwa chakukula pang'onopang'ono kwa Mycoplasma, kuyezetsa kutengeka kwa mankhwala mu vitro kungachedwetse chithandizo.Kafukufuku wasonyeza kuti domain II (nucleotide 748) ndi domain V (Masinthidwe mu nucleotides 2059 ndi 2060) amagwirizana ndi kuwonjezeka kukana kwa macrolides.Chifukwa chake, kutengeka kwa M. bovis ku mankhwala a macrolide kumatha kupezedwa mwachangu poyesa mamolekyulu a kusinthaku.
Zamkatimu
≥ 98%
Kufotokozera
Company muyezo
Hebei Veyong pharmaceutical Co., Ltd, unakhazikitsidwa mu 2002, ili mu Shijiazhuang City, Hebei Province, China, pafupi ndi Capital Beijing.Ndi kampani yayikulu yovomerezeka ya GMP yotsimikizira za Chowona Zanyama, yokhala ndi R&D, kupanga ndi kugulitsa ma API a Chowona Zanyama, kukonzekera, zakudya zosakaniza ndi zowonjezera zowonjezera.Monga Provincial Technical Center, Veyong yakhazikitsa njira yatsopano ya R&D yamankhwala atsopano azowona zanyama, ndipo ndi kampani yodziwika bwino yaukadaulo yozikidwa pazanyama, pali akatswiri 65 aukadaulo.Veyong ili ndi zoyambira ziwiri zopangira: Shijiazhuang ndi Ordos, pomwe maziko a Shijiazhuang amatenga malo a 78,706 m2, okhala ndi zinthu 13 za API kuphatikiza Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, ndi 11, mizere yopangira jekeseni, njira yopangira jekeseni. , premix, bolus, mankhwala ndi mankhwala ophera tizilombo, ects.Veyong imapereka ma API, zokonzekera zolembera zopitilira 100, ndi ntchito za OEM & ODM.
Veyong amawona kufunikira kwakukulu ku kasamalidwe ka EHS(Environment, Health & Safety) system, ndipo adalandira ziphaso za ISO14001 ndi OHSAS18001.Veyong adalembedwa m'mabizinesi omwe akutuluka m'chigawo cha Hebei ndipo amatha kuonetsetsa kuti zinthu zikuyenda bwino.
Veyong adakhazikitsa dongosolo lathunthu la kasamalidwe kaubwino, adapeza satifiketi ya ISO9001, satifiketi ya China GMP, satifiketi ya APVMA GMP ya Australia, satifiketi ya GMP ya Ethiopia, satifiketi ya Ivermectin CEP, ndipo idapita ku US FDA.Veyong ali ndi gulu la akatswiri olembetsa, malonda ndi ntchito zaukadaulo, kampani yathu idadalitsidwa ndi chithandizo kuchokera kwamakasitomala ambiri ndi mtundu wabwino kwambiri wazinthu, zogulitsa zapamwamba kwambiri komanso ntchito zotsatsa pambuyo pa malonda, kasamalidwe kakulu ndi sayansi.Veyong wapanga mgwirizano wautali ndi mabizinesi ambiri odziwika padziko lonse lapansi ogulitsa nyama ndi zinthu zomwe zimatumizidwa ku Europe, South America, Middle East, Africa, Asia, etc. mayiko ndi zigawo zopitilira 60.
