250mg Triclabendazole Bolus
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Zochita za Pharmacological
Pharmacodynamics Triclobendazole ndi m'gulu la benzimidazole mankhwala, amagwiritsidwa ntchito makamaka kukana Fasciola hepatica, ndipo ali ndi zotsatira zoonekeratu kupha Fasciola hepatica a mibadwo yosiyanasiyana.mankhwala a fluke.Pambuyo mankhwala odzipereka, izo kumasokoneza microtubule dongosolo ndi ntchito tiziromboti, linalake ndipo tikulephera amasulidwe tiziromboti hydrolytic proteases.Zotsatira za triclobendazole pa nyongolotsi zimasiyanasiyana malinga ndi kuchuluka kwake, monga akuluakulu omwe ali otsika (1 ~ 3μg/ml)
Mankhwalawa amakhalabebe ndi moyo kwa maola a 24, ndipo ntchitoyo imafooka kwambiri m'magulu apamwamba (10-25μg / ml) kwa maola 24;kuchuluka kwa 25-50μg/ml kumalepheretsa kwathunthu kwa maola 24.Koma tcheru kwambiri mphutsi.Pa 10 μg/ml, ntchito yonse ya maola 24 idaletsedwa.
Pharmacokinetics
The bioavailability wa triclobendazole ndi mkulu.Pambuyo pakamwa pakamwa pa 10 mg/kg kulemera kwa mbuzi ndi nkhosa, mlingo waukulu wa plasma unafika 15 μg/ml mu maola 24 mpaka 36, ndipo magazi a triclobendazole ndi metabolites ake anali apamwamba.Mtengo wapamwamba wa mankhwalawa ndi 5 mpaka 20 kuposa wa benzimidazole anthelmintics, ndipo theka la moyo wochotsa ndi pafupifupi maola 22.Triclobendazole makamaka oxidized mu nkhosa ndi makoswe kuti sulfone ndi zotumphukira sulfoxide, amene amamanga kuti albumin ndi kulimbikira plasma kuposa 7 masiku.Kuchuluka kwa plasma ndikumanga kwa albumin m'madzi a m'magazi kumawoneka kuti kumalumikizidwa ndi nthawi yayitali ya antifascioli.Pambuyo pa masiku 10 a mankhwala a nkhosa, pafupifupi 95% ya mankhwalawa amachotsedwa mu ndowe, 2% amachotsedwa mumkodzo, ndipo osachepera 1% amachotsedwa mkaka.
Zochita ndi Zogwiritsa Ntchito
Benzimidazole anti-fasciola mankhwala.Amagwiritsidwa ntchito kwambiri popewa komanso kuchiza matenda a Fasciola hepatica mu ng'ombe ndi nkhosa.
Zoyipa
Palibe zoyipa zomwe zawoneka zikagwiritsidwa ntchito molingana ndi momwe amagwiritsidwira ntchito komanso mlingo wake
Kusamalitsa
(1) Wopunduka popanga mkaka.
(2) Nsomba ndizoopsa kwambiri, ndipo chidebe chamankhwala chotsalira sichiyenera kuipitsa gwero la madzi.
(3) Anthu amene sagwirizana ndi mankhwala ayenera kupewa kukhudza khungu ndi kupuma movutikira akamawagwiritsa ntchito, kuvala magolovesi akamamwa mankhwala, komanso kuletsa kudya, kumwa ndi kusuta.
(4) Sambani m’manja mutapaka
Nthawi yochotsa
ng'ombe ndi nkhosa masiku 56
Kusungirako
Sungani pamalo ochepera 30 ℃.
Hebei Veyong pharmaceutical Co., Ltd, unakhazikitsidwa mu 2002, ili mu Shijiazhuang City, Hebei Province, China, pafupi ndi Capital Beijing.Ndi kampani yayikulu yovomerezeka ya GMP yotsimikizira za Chowona Zanyama, yokhala ndi R&D, kupanga ndi kugulitsa ma API a Chowona Zanyama, kukonzekera, zakudya zosakaniza ndi zowonjezera zowonjezera.Monga Provincial Technical Center, Veyong yakhazikitsa njira yatsopano ya R&D yamankhwala atsopano azowona zanyama, ndipo ndi kampani yodziwika bwino yaukadaulo yozikidwa pazanyama, pali akatswiri 65 aukadaulo.Veyong ili ndi zoyambira ziwiri zopangira: Shijiazhuang ndi Ordos, pomwe maziko a Shijiazhuang amatenga malo a 78,706 m2, okhala ndi zinthu 13 za API kuphatikiza Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, ndi 11, mizere yopangira jekeseni, njira yopangira jekeseni. , premix, bolus, mankhwala ndi mankhwala ophera tizilombo, ects.Veyong imapereka ma API, zokonzekera zolembera zopitilira 100, ndi ntchito za OEM & ODM.
Veyong amawona kufunikira kwakukulu ku kasamalidwe ka EHS(Environment, Health & Safety) system, ndipo adalandira ziphaso za ISO14001 ndi OHSAS18001.Veyong adalembedwa m'mabizinesi omwe akutuluka m'chigawo cha Hebei ndipo amatha kuonetsetsa kuti zinthu zikuyenda bwino.
Veyong adakhazikitsa dongosolo lathunthu la kasamalidwe kaubwino, adapeza satifiketi ya ISO9001, satifiketi ya China GMP, satifiketi ya APVMA GMP ya Australia, satifiketi ya GMP ya Ethiopia, satifiketi ya Ivermectin CEP, ndipo idapita ku US FDA.Veyong ali ndi gulu la akatswiri olembetsa, malonda ndi ntchito zaukadaulo, kampani yathu idadalitsidwa ndi chithandizo kuchokera kwamakasitomala ambiri ndi mtundu wabwino kwambiri wazinthu, zogulitsa zapamwamba kwambiri komanso ntchito zotsatsa pambuyo pa malonda, kasamalidwe kakulu ndi sayansi.Veyong wapanga mgwirizano wautali ndi mabizinesi ambiri odziwika padziko lonse lapansi ogulitsa nyama ndi zinthu zomwe zimatumizidwa ku Europe, South America, Middle East, Africa, Asia, etc. mayiko ndi zigawo zopitilira 60.
